The strengths of our NexTgen Ultrasonic Core generator technology have enabled us to expand our product offering into the MedTech sector, covering therapeutic applications, microfluidics, and biological sample preparation.
Our wide range of high- and low-frequency generators, easily integrated into compact systems, provides a unique advantage in delivering ultrasound solutions tailored to your specifications.
Our development and production capabilities ensure cost-effective solutions, whether your needs involve a few units or several hundred systems.
SinapTec operates exclusively as a provider of ultrasound technologies for research, experimentation, and system integration projects.
Therapeutic Ultrasound
I. HIFU Technology (High-Intensity Focused Ultrasound)
Ultrasound-based therapeutic applications offer a modern approach to treating severe conditions through the non-invasive focusing of ultrasound waves, enabling the targeted destruction of cells within the body.
HIFU (High-Intensity Focused Ultrasound) is a non-invasive therapeutic technology that uses high-intensity focused ultrasound to selectively destroy diseased tissues, particularly in the treatment of certain cancers and fibroids.
This technology offers a major advantage over other therapeutic solutions by minimizing side effects following treatment.
Two fundamental physical mechanisms are responsible for the desired biological effects:
🔹 Thermal effect: localized heating of tumor cells to induce their destruction.
🔹 Acoustic cavitation: mechanical destruction of tumor cells through a brief but highly intense acoustic field.
A key advantage of this technology lies in the precision of ultrasound focusing, which reduces the impact on surrounding healthy tissues. The treatment volume decreases as frequency increases, enabling more targeted interventions.
Operating Frequencies :
🔹From 0,5 to 5 MHz → The treatment volume descreases as frequency increases
Applied across multiple sectors:
🔹Medical 🔹Research
II. LIFU Technologies (Low-Intensity Focused Ultrasound)
LIFU is a non-invasive technology that uses low-intensity focused ultrasound to target specific regions of the brain without surgery or implantation.
Through the mechanical effects induced by ultrasound, LIFU enables controlled modulation of neuronal activity without causing tissue damage.
With its high spatial precision, adjustable depth of action, and contactless operation, LIFU is now widely used in neuroscience research. It serves as a valuable tool for exploring the mechanisms underlying brain function regulation, particularly in research scenarios requiring targeted stimulation or modulation of deep brain structures.
A LIFU system is based on several key components:
🔹A focused ultrasound transducer which concentrates ultrasound waves into a small focal volume.
🔹 A focused ultrasound transducer High-frequency ultrasound generator, which delivers the appropriate signals and manages the system’s operating conditions (frequency, power, pulse duration, signal performance control, protection, etc.). Our NexTgen technology has been specifically adapted for this type of application.
Operating frequencies:
🔹 0.2 to 1 MHz → for penetrating the skull
The main applications are:
🔹 Ultrasound neuromodulation is being studied as a potential treatment for neurological disorders and is of particular interest in neuroscience research for exploring brain functions.
🔹 Targeted and transient opening of the blood–brain barrier to facilitate controlled drug delivery to specific regions of the brain.
Low-frequency ultrasound refers to ultrasonic waves characterized by relatively long wavelengths and offering strong potential for therapeutic and biomedical applications. Due to their lower frequency, these ultrasounds provide greater penetration into biological tissues and, at equivalent acoustic pressure, can act on deeper structures, although their directivity remains relatively limited.
In biological tissues, low-frequency ultrasound can induce various biological effects, mainly mechanical effects, thermal effects, acoustic cavitation, as well as associated sonochemical effects. Based on these properties, low-frequency ultrasound is widely used in the medical and biomedical fields, particularly in exploratory clinical research, in vitro experiments, and animal model studies.
Frequency range:
Between 20 kHz and 1 MHz
Our low-frequency ultrasound technologies are integrated into various types of medical devices across several application areas, including:
- Ultrasound-assisted phacoemulsification
- Ultrasound-assisted bone strengthening
Biotechnology Applications of Ultrasound
In the field of biotechnology, ultrasonic technologies are recognized for their ability to interact precisely with biological systems, enabling the manipulation, processing, and analysis of cells, tissues, and complex biological environments.
With expertise across a wide frequency range (from 20 kHz to 10 MHz), SinapTec develops electronic solutions and ultrasonic modules tailored to various biotech applications, including:
Sonoporation for gene therapy
→ Ultrasound enables the temporary permeabilization of the cell membrane, facilitating the introduction of genetic material (DNA, RNA, etc.) into cells before the membrane restores its integrity.
Ultrasound in microfluidics: mixing, separation, and flow manipulation
→ Ultrasound enables precise control of fluid flows at the microscale, as well as homogeneous mixing and the separation of particles or cells.
Cell lysis
→ Ultrasound can be used to induce controlled disruption of cell membranes for biological sample preparation and analysis.
